By Gaetano Santulli
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Extra resources for Angiogenesis: Insights from a Systematic Overview
Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med 2003;348:593-600.  Peichev M, Naiyer AJ, Pereira D et al. Expression of VEGFR-2 and AC133 by circulating human CD34+ cells identifies a population of functional endothelial precursors. Blood 2000;95:952-8.  Lin Y, Weisdorf DJ, Solovey A, Hebbel RP. Origins of circulating endothelial cells and endothelial outgrowth from blood. J Clin Invest 2000;105:71-7.  Yamaguchi J, Kusano KF, Masuo O et al.
These receptors bind with distinct selectivity. The receptor tyrosine kinases PDGFR-alpha and -beta, expressed on EC and SMC, PDGF-B and PDGFR-beta play essential roles in the stabilization of nascent blood vessels via coverage with SMC. PDGF-BB is expressed by endothelial cells and its receptor, PDGF-beta, is located in vascular smooth muscle cells and pericytes. Recently, two additional growth factors have been identified in this family: PDGF-C and D. In contrast to A and B, the novel PDGFs are secreted as zymogens and require activation by proteolytic cleavage of their N-terminal CUB domains.
Ribatti D, Vacca A, Nico B, Ria R, Dammacco F. Cross-talk between hematopoiesis and angiogenesis signaling pathways. Curr Mol Med 2002;2:537-43. Takakura N, Watanabe T, Suenobu S et al. A role for hematopoietic stem cells in promoting angiogenesis. Cell 2000;102:199-209. Angiogenesis: Something Old, Something New 25  Shalaby F, Rossant J, Yamaguchi TP et al. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature 1995;376:62-6.  Asahara T, Isner JM. Endothelial progenitor cells for vascular regeneration.