By Henry G. Kunkel, Frank J. Dixon (Eds.)
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Adult immune-defective mice resemble the B cells of normal neonatal mice, but not bone marrow B cells of adult normal mice with regard to their susceptibility to tolerance induction. A different approach to the analysis of the tolerance susceptibility of immune-defective mice was taken by McKearn and Quintans (1980), who preincubated the tolerogen TNP-fowl y-globulin (TNP-FGG) with B cells of immune-defective or normal mice prior to challenge with the TI-1 antigens TNP-BA or TNP-LPS. 94 ? 74 ?
1978b). D. SUSCEPTIBILITY TO TOLERANCE The susceptibility of CBA/N B cells to tolerance induction was of particular importance in view of the functional defects demonstrated in these cells when analyzed with TI-2 antigens or B-cell mitogens. A number of approaches have been employed in studies on this subject (E. , 1978a,b). In early studies it had been demonstrated that a larger proportion of neonatal splenic B cells and a smaller proportion of adult bone marrow B cells were sensitive to tolerance induction when exposed to a tolerogen i n vitro (E.
1980). , 1980). 3%), or lymph node cells than their normal F, female littermates. B. , 1975). , 1980). , 1980). Although the ratio of p vs 6 radioactivity in the defectives resembled that observed in the spleens of neonatal normal mice, it was not clear if this similarity was due to a high incidence of p+6- cells in the immune-defective mice. , 1976a, 1980), which can quantitatively determine the amount of fluorescence on individual lymphoid cells. , 1976a). Thus, whereas approximately 24% of the surface IgM-bearing cells in normal adult mice bore relatively high densities of surface IgM, approximately 63% of surface IgM-bearing cells from adult CBNN mice had this characteristic (Fig.