Download Advances in Immunology, Vol. 29 by Henry G. Kunkel and Frank J. Dixon (Eds.) PDF

By Henry G. Kunkel and Frank J. Dixon (Eds.)

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When bound to an activator, the ability of C3b to bind P1H is diminished and, consequently, formation of C 3 convertase (C3b,Bb) and amplification commence. , 1976a,c). , 1978). The active site responsible for C 3 and C 5 cleavage resides in the Bb subunit of the enzyme. , ALTERNATIVE PATHWAY OF COMPLEMENT 29 1976a). , 1976a,c). , 1977)Binding-activation of properdin results in stabilization of the enzyme such that its half-life at 37°C increases to 10 minutes. ” This form is able to bind to C3b directly without the aid of factor B, but it retains the ability to stabilize the preformed enzyme.

The difference between the pathways are these: The antibody-dependent classical pathway has in C l q a unique recognition protein, whereas the antibody-independent alternative pathway utilizes for recognition bound C3b that has many other functions. Second, whereas the alternative pathway is endowed with a unique amplification mechanism, the classical pathway is devoid of such a mechanism. 30 HANS J. MULLER-EBERHARD AND ROBERT D. SCHFWIBER VIII. The Cytolytic Alternative Pathway That the alternative pathway is potentially cytolytic has been known for a number of years.

MULLER-EBERHARD AND ROBERT D. IIID PHASE (‘3 C‘ONVERTASE ((‘3. B. 8. Molecular concept ofthe alternative pathway. “Control”represents the situation that would exist in the fluid phase or upon introduction of a nonactivator particle. “Restricted control” would occur upon introduction of a pathway activator. C3b* denotes nascently formed C3b before decay of its metastable binding site. , 1978). is at least a two-step process involving random deposition of C3b on the activator particle through its metastable binding site and discriminatory interaction of bound C3b with surface markers.

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