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Other accidental plant mixtures are unfortunately mentioned every year. , Tussilago sp. ) contain alkaloids characterized by a pyrrolizidine nucleus. The presence of a double bond in position 1-2 and of an ester in position 9 confers a particular hepatotoxicity to these alkaloids. Their toxicity increases with the degree of esterification, with a macrocyclic diester being more toxic than a monoester. ; ACS Symposium Series; American Chemical Society: Washington, DC, 1998. ch002 24 Furthermore, the longer the acid chain is, the more toxic the molecule will be.

7. M. F. Eds. Springer Verlag: Berlin, 1993, vol. 2, pp 1-90. 8. WHO. Report of the Sixth International Conference of Drug Regulatory Authorities in Ottawa, Canada, October 1991, pp 73-80. 9. Keller, K. European Phytotelegram 1994 (6), 40-47. 10. Keller, K. Proceedings of the 3rd International Conference on Pharmacopoeias and Quality Control of Drugs, Rome, November 1992, pp 243-250. 11. Steinhoff, B. Br. J. Phytother. 1993-94, 3 (4), 190-193. 12. Steinhoff, B. Br. J. Phytother. 1993-94, 3 (2), 76-80.

Chaste Tree fruits (Vitex agnus-castus) • Irregularities of the menstrual cycle. • Premenstrual complaints. • Mastodyma. Note: In case of feeling of tension and swelling of the breasts and at disturbances of menstruation, a physician should be consulted for diagnosis. Daily dosage: aqueous-alcoholic extracts corresponding to 30-40 mg of the drug. German Chamomileflower(Matricaria recutita) • Externally: Skin and mucous membrane inflammations, as well as bacterial skin diseases, including those of the oral cavity and gums.

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