By National Research Council, Board on Environmental Studies and Toxicology, Committee on Toxicology, Committee on Acute Exposure Guideline Levels
This e-book is the 6th quantity within the sequence Acute publicity instruction degrees for Selected Airborne Chemicals, and contains AEGLs for chemical substances resembling ammonia, nickel carbonyl and phosphine, between others.
At the request of the dep. of safeguard, the nationwide examine Council has reviewed the correct medical literature compiled by means of knowledgeable panel and confirmed Acute publicity guide degrees (AEGLs) for 12 new chemical compounds. AEGLs symbolize publicity degrees under which opposed well-being results aren't more likely to happen and are worthy in responding to emergencies resembling unintentional or intentional chemical releases locally, the place of work, transportation, the army, and for the remediation of infected sites.
Three AEGLs are licensed for every chemical, representing publicity degrees that bring about: 1) extraordinary yet reversible pain; 2) long-lasting healthiness results; and three) life-threatening wellbeing and fitness impacts.
Read Online or Download Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 6 PDF
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Extra resources for Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 6
Developmental/Reproductive Toxicity No studies were located that assessed in vivo effects of allylamine exposure on animals. The embryotoxic potential of allylamine was estimated using the in vitro Chick Embryotoxicity Screening Test (CHEST) and fertilized eggs from White Leghorn fowl (Jelinek et al. 1985). , highest ineffective concentration to lowest effective concentration). Application of 3-30 µg allylamine to 2- to 4-day-old embryos until day 8 did not result in body malformations; the mortality rate was 48%.
The same AEGL-2 value was adopted for 10-60 min because the degree of irritation from exposure for 5 min was not expected to increase over a 1-h period beyond the scope of AEGL-2. The 4- and 8-h AEGL-2 values were derived from the Guzman et al. 7 in ten Berge et al. (1986) concentration-time relationship equation Cn × t = k. In the Guzman et al. study, male Long-Evans rats were exposed to 20-100 ppm of allylamine for 4-48 h (shown in Table 1-5), and the responses designated as “+” for histologic heart changes were used in the regression analysis to obtain n.
After 10 exposures, pathologic changes seen in the heart varied from inflammation of the smaller arteriole walls to focal necrosis of large areas of muscle bun- Copyright © National Academy of Sciences. All rights reserved. Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 6 28 Acute Exposure Guideline Levels dles. Similar but more severe changes occurred after 20 exposures, and “stages of healing” were seen in some areas. Heart lesions seen after 40 exposures appeared different: They were not “acute” and consisted of fragmentation of muscle bundles with replacement by loose edematous fibrous tissue, as well as edema in the arteriole outer coat.