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Inflammatory mediator-induced hypothalamic-pituitary-adrenal axis activation in defective streptococcal cell wall arthritis-susceptible Lewis rats, Proc. Natl. Acad. Sci. USA, 86, 2374, 1989. 56 References ............................................................................................... 1 Tryptophan: Biochemistry and Health Implications Introduction This chapter discusses the pathways by which L-tryptophan is metabolized into a variety of metabolites, many of which have important physiological functions.

It is also of interest to note that certain proteins have their tryptophan residues concentrated at one end of the protein chain, and that the tryptophan residues are often in a regular, repeating configuration. In view of the relatively strong binding between tryptophan sidechains and purine bases, it is tempting to speculate that the tryptophan residues in such proteins may be important in orienting and attaching such proteins to nucleic acids of virus nucleic acid cores. Similarly, binding of tryptophan residues to phospholipids27 may be important in orienting certain receptor proteins in phospholipid membranes of cells.

4, 47, 1995. 8. , Strange, C. , 1, 1287, 1982. 9. , Molecular genetics of L-tryptophan 2,3-dioxygenase in rat liver, in Progress in Tryptophan and Serotonin Research 1986, Bender, D. , Joseph, M. , Walter de Gruyter, Berlin, 1987, 1–6. 10. , Cornel, A. , Dotson, E. , Collins, F. , and Besansky, N. , The tryptophan oxygenase gene of Anopheles gambiae, Insect Biochem. Mol. , 26, 525, 1996. 11. Besansky, N. , Benedict, M. , Rafferty, C. , Hamm, D. , The Anopheles gambiae tryptophan oxygenase gene expressed from a baculovirus promoter complements Drosophilia melanogaster vermilion, Insect Biochem.

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